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How Advances In Neurodegenerative Diseases Can Improve Preci...
Article, Precision Medicine

How Advances In Neurodegenerative Diseases Can Improve Precision Medicine

The brain is a tremendously complicated organ that may be the most essential component of our body.

It regulates all of our bodily systems and allows us to learn new things.

Parkinson’s disease, Alzheimer’s disease, and multiple sclerosis are examples of illnesses that can have an effect on us.

In recent years, there has been a significant advancement in the treatment of these sorts of neurodegenerative illnesses since we now understand what causes them and how they progress over time.

What is a neurodegenerative disease?

Neurodegenerative diseases are disorders which result in the progressive deterioration of brain functions such as memory, speech, and motor control.

The most common neurodegenerative diseases include Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis (ALS).

Neurodegenerative diseases can be either inherited or acquired.

They may also be caused by toxins (e.g., alcohol), infections (e.g., Creutzfeldt-Jakob disease), or degeneration of neurons due to age or head trauma associated with diseases 

  • According to the Alzheimer’s Association, more than 6 million people in the United States have Alzheimer’s disease. Furthermore, the illness kills more individuals than breast and prostate cancer combined and contributes significantly to high healthcare expenses.
  • Parkinson’s disease is also associated with significant healthcare expenditures and effects. In the United States, about one million people have the illness, and 60,000 more are identified each year. That is higher than the total number of persons diagnosed with multiple sclerosis, muscular dystrophy, and Lou Gehrig’s disease, according to the Parkinson’s Foundation.

What are the effects of illnesses on people? How might neurodegenerative illnesses be treated better?

Cases of Alzheimer’s and Parkinson’s disease are anticipated to rise during the next 10 years, putting further burden on the healthcare system.

However, by obtaining molecular understanding into how toxic proteins influence neurodegenerative disorders, researchers can discover therapeutic targets to address the condition.

Although neither Alzheimer’s nor Parkinson’s disease has a cure, developing chronic disease management therapies has the potential to improve the quality of life for those living with neurodegenerative illnesses.

While cells inevitably age and die, effective control of cellular proteins is critical in keeping a healthy brain as people become older.

Protein aggregates, on the other hand, spread to nearby cells in neurodegenerative disorders.

Unfortunately, despite the fact that the hazardous substance does spread, it is still unclear how it does so.

How are breakthroughs in neurodegenerative illness assisting doctors in pursuit of precision medicine?

The Rutgers researchers looked at roundworms whose stressed nerve cells may eject neurotoxic proteins in huge packets called exophers, as well as how different stressors affect this extrusion.

The researchers revealed that exophers require particular physiological signals to develop and that fasting greatly enhances exopher synthesis.

“By establishing an initial molecular model for fasting-induced exopler elevation in neurons, we report molecular information and insight into the regulation of cumulative transfer biology relevant to the fundamental mysteries of neurodegenerative diseases,”

Jason Cooper, a postdoctoral research fellow in the Department of Molecular Biology and Biochemistry at the University of California, Berkeley.

“Toxic proteins disseminate to adjacent cells in neurodegenerative disorders, causing cell death. Given the relevance of protein aggregate management in aging and neurodegenerative disorders, as well as the poorly known biology of how those aggregates are transported, comprehensive knowledge of the transfer process may identify previously undiscovered therapeutic targets.”

What are the key takeaways from this?

Advances in neurodegenerative diseases have the potential to improve precision medicine, which is why researchers must continue to fight back against these disorders.

With the advances that have been made in neurodegenerative diseases, researchers can now turn their attention to precision medicine development by identifying therapeutic targets and improving patient outcomes.


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