Please Add Widget from here
Gene Silencing Crushes Crippling Pain
Innovation, News, Precision Medicine, Wellbeing

Gene Silencing Crushes Crippling Pain

Scientists at the University of California, San Diego School of Medicine have created a new class of drugs that can shut down a gene’s ability to produce proteins.

The breakthrough could lead to transformative treatments for diseases caused by an overactive gene or genes, such as type-2 diabetes and cystic fibrosis.

The newly developed drugs are called small interfering RNAs, or siRNAs. In a study published online in the journal Nature, researchers showed that siRNAs reduce hyperactive protein production.

Scientists have known for some time that genes can be silenced by small pieces of RNA called microRNAs (miRs).

These tiny molecules don’t just block the expression of certain genes, they also inhibit cellular pathways.

This gives them a powerful tool to investigate and possibly treat diseases.

What is gene silencing?

Gene silencing is a process by which the expression of a specific gene is inhibited, either through increased transcriptional repression or decreased transcriptional activation.

Gene silencing may be compared to gene activation in that both processes regulate gene expression, but while gene activation increases the production of an enzyme at the ribosome level, gene silencing acts by preventing this action from taking place.

The mechanism depends on the type of RNA: there are several types of small RNAs and microRNAs (miRNA) that can suppress one or more mRNAs, and it has been suggested that each type of ncRNA.

How gene silencing is used in medicine

Genetic engineering is used to change the genetic makeup of a living organism by manipulating its DNA. This may be done for many reasons, including increasing crop yields and improving the quality of livestock.

Gene silencing (also known as gene knockdown or gene suppression) refers to techniques that reduce the expression of a particular gene product (a messenger RNA, an enzyme, a functional non-coding RNA).

It can be achieved through inhibition of transcription or translation, through small inhibitory RNAs (siRNAs), or through epigenetic modifications such as histone modification.

Gene silencing can also be achieved by stimulating.

The use of gene silencing in medicine is a subject that few people have heard about.

It has been used by scientists for over a decade, but it’s only recently become a hot topic among the general public.

In this blog post, I will explain how gene silencing works and why you might need it to treat your illness.

Gene silencing for pain management!

Rather than merely addressing the sisters’ symptoms, gene silencing targets the disease’s fundamental cause. Porphyria causes a build-up of harmful proteins in the body, which causes physical discomfort.

Gene silencing “mutes” a set of genetic instructions, preventing the creation of that protein.

Clinical trials have demonstrated the gene silencing therapy, called givosiran, cut the number of serious threats by 74 percent.

The National Institute for Health and Clinical Excellence (NICE), which endorses drugs for use in England, said the medication “would enhance people’s standard of living” and was “bang for the buck”.

Gene silencing has already been shown to be successful in the treatment of other uncommon genetic disorders, such as amyloidosis.

It has already been used as a twice-yearly cholesterol-busting shot due to its capacity to change how DNA operates in the human body without permanently affecting it.

Gene silencing, according to Tara Moore, a professor of personalized medicine at the University of Ulster, has the potential to be as large as antibiotics.

The future of gene silencing medicine

Gene silencing medicine is the new big thing in the world of pharmaceuticals.

It’s an emerging field that focuses on RNA, or ribonucleic acid, which is the molecule responsible for translating our DNA into proteins.

RNA has been around longer than DNA and it has two important functions: to read information from our genes and to translate that information into proteins.

The study of this system can help us understand how cells work and develop drugs that treat diseases like cancer or viral infections.

The future of gene-silencing medicine looks promising because we’re able to target specific genes.

Very cool and revolutionary technology is about to be available for gene silencing.

It is called CRISPR and it will be able to edit any species of DNA, including human DNA.

CRISPR has been making headlines recently because scientists have used the technology to remove HIV from infected cells in a living organism.

This is just one example of how CRISPR can potentially save millions of lives by curing genetic diseases before they even occur.

Gene therapy may also be able to treat other illnesses such as Alzheimer’s, cancer, diabetes, obesity, and more. Even though this technology has huge potential.


The medical breakthrough of gene silencing medicine is one that will change the lives of people who have been suffering from debilitating diseases for years.

Targeting pain, in particular, this new treatment can help many different kinds of illnesses.

The idea that gene silencing can be used to treat chronic pain has been around for some time, but only recently have advancements in the field made it possible.

With new therapies on the horizon, many people are excited about what this treatment could mean for them.


A passionate explorer, content enthusiast, and a people's person. I love exploring different societies and learn their cultures!

Leave a Comment

Your email address will not be published.