Please Add Widget from here
Cancer Breakthrough. UMass Team Engineers Nanoparticle
Innovation, News, Pharma, Precision Medicine, Short

Cancer Breakthrough. UMass Team Engineers Nanoparticle

A nanoparticle that has the potential to revolutionise disease treatment, including cancer, has been engineered by a team of researchers at the Centre for Bioactive Delivery at the University of Massachusetts.

The research combines two approaches to increase precision and effectively deliver treatment to the specific cells affected by cancer.

Two of the most promising new treatments involve the delivery of cancer-fighting drugs via biologics or antibody-drug conjugates (ADCs). 

Biologics or biologic drugs are products made from living organisms or contain components of living organisms.

Biologics can directly substitute for a malfunctioning protein in cells. Meaning they have less serious side effects than traditional chemotherapy. However, due to their size, they are unable to get into specific cells.

ADCs are a new class of highly potent biological drugs built by attaching a small molecule anticancer drug or another therapeutic agent to an antibody. The antibody targets a specific antigen only found on target cells. 

ADCs can target specific malignant cells with microdoses of therapeutic drugs, but the antibodies can only carry a limited drug cargo. 

Since ADCs are more toxic than biologics, increasing the dose of ADCs increases the risk of harmful side effects.

The nanoparticle, called “protein-antibody conjugate” or PAC, contains antibodies that, as Sankaran Thayumanavan described, are like an address on an envelope and the cancer-fighting protein is the contents of that envelope. 

The PAC allows us to deliver the envelope with its protected treatment to the correct address. So, safer drugs are delivered to the right cell… the result would be a treatment with fewer side effects.

Sankaran “Thai” Thayumanavan – Interim Head of Biomedical Engineering at UMass

“The PAC allows us to deliver the envelope with its protected treatment to the correct address. So, safer drugs are delivered to the right cell… the result would be a treatment with fewer side effects”

At the heart of the PAC is a “polymer brush,” a nanoparticle that the team engineered. This brush does two things. 

First, it is studded with antibodies that are capable of locating individual cancerous cells. Next, the brush has to both hold a sizable cargo of biologics but also keep that dose intact. 

The team found that their nanoparticle could carry four times the therapeutic dose of a typical ADC, and, through a variety of techniques, could be increased many times over.

What our team has done, is to combine the advantages of biologics and ADCs and address their weaknesses. It is a new platform for cancer therapy.

Khushboo Singh – Study Lead Author

The team’s research represents a major milestone in cancer research and their findings could extend far beyond that. 

Bin Liu, one of the paper’s lead authors, believes that the research will extend far beyond cancer to all sorts of genetic diseases or any abnormality that occurs inside a human cell. 

Among the implications, perhaps the most exciting part is that this opens the door to develop cures for certain cancers that have been long considered undruggable or incurable.

Sankaran “Thai” Thayumanavan

Source: University of Massachusetts

Paper: Angewandte Chemie

coinmag

I first joined HLTH.network as an intern back in early 2021 and now operate as one of HLTH.network's operations managers. It is a great way to be a part of the digitalization of healthcare, and it is so important that we work towards a market with valuable patient-centered data. Every single person on the planet has a stake in healthcare, but not everyone has equal access. We are working to change that.

  1. fewmflxhm hodvf extrymg iwfz krbddsqjuwyfxpl

  2. 38823 100339Cause thats required valuable affiliate business rules to get you started on participating in circumstances appropriate for your incredible web-based business concern. Inernet marketing 516077

  3. 466596 396142Usually I do not read post on blogs, however I would like to say that this write-up extremely forced me to have a look at and do so! Your writing taste has been surprised me. Thank you, quite great post. 209153

  4. 177276 646611Some genuinely wonderful blog posts on this internet web site , thankyou for contribution. 18957

  5. 653706 953740Hello super schner Webblog den ihr da habt. Bin gerade ber die Google Suche darber gestolpert. Gefllt mir echt super gut. macht weiter so. MFG Martina 272081

  6. graliontorile

    November 6, 2022

    Very good website you have here but I was curious about if you knew of any message boards that cover the same topics discussed here? I’d really like to be a part of community where I can get suggestions from other experienced people that share the same interest. If you have any suggestions, please let me know. Thanks!

  7. 841842 531043Dead pent subject matter, thanks for entropy. 302919

  8. 761242 409960i was just surfing along and came upon your weblog. just wanted to say excellent job and this post actually helped me. 304236

  9. 155185 293317Up to now, you call for to term of hire an absolute truck or van and will also be removal equipments to valuable items plus check out the new destination. From the long run, which finish up with are couple of items except anxiety moreover stress and anxiety. removals stockport 256365

  10. 623495 511589Music began playing any time I opened this web page, so frustrating! 518320

  11. 649420 239982The electronic cigarette uses a battery and a small heating factor the vaporize the e-liquid. This vapor can then be inhaled and exhaled 838884

  12. 895924 80453Precisely what I was looking for, thankyou for putting up. 322249

  13. 483402 452550Gnarly article mate, keep the good work, just shared this with ma friendz 124971

  14. 169491 214852Fantastic post, thanks so a lot for sharing. Do you happen to have an RSS feed I can subscribe to? 242968

  15. 115489 355303Youre so cool! I dont suppose Ive learn something like this before. So good to search out any person with some unique thoughts on this topic. realy thanks for starting this up. this site is 1 thing thats wanted on the net, somebody with a bit originality. valuable job for bringing one thing new to the internet! 162173

  16. 504890 808963It is hard to search out knowledgeable individuals on this subject, but you sound like you realize what youre speaking about! Thanks 665512

  17. 283265 701569Largest lover messages were produced to share it together with your and gives honour with the bride and groom. Quite sound systems facing unnecessary throngs of people need to take into account each of our valuable concept of all presenting, which is ones trailer. very best man toasts 305552

  18. Greetings! Very useful advice in this particular post! It’s the little changes that make the most significant changes.
    Thanks for sharing!

  19. 319005 384233You created some decent points there. I looked online for the issue and located a lot of people could go as properly as making use of your internet internet site. 778251

  20. 229946 480237you got a really excellent web site, Sword lily I located it via yahoo. 586494

  21. 742742 783931I like this internet internet site extremely a lot, Its a truly nice billet to read and obtain information . 177152

  22. 334192 764257dress shops that offer discounts are extremely common in our place and i always shop at them,. 929957

  23. 546085 240384Thanks for this outstanding. I was wondering whether you were planning of writing comparable posts to this one. .Keep up the outstanding articles! 855088

  24. 483631 102795Hello! Great stuff, please maintain us posted when you post again something like that! 127951

  25. 676510 492149woah i like yur site. It truly helped me with the information i wus looking for. Appcriciate it, will bookmark. 707893

  26. 395095 955842This can indicate that a watch has spent some or all of its life in the tropics and was not serviced as regularly as it need to have been. 148207

Leave a Comment

Your email address will not be published. Required fields are marked *